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2 major and 2 minor criteria or 1 major and 4 minor criteria. Major criteria are: ALMS1 mutation in 1 allele and/or family history of Alström syndrome. Vision pathology (history of nystagmus in infancy/childhood, legal blindness, cone and rod dystrophy by ERG). Minor criteria: Obesity and/or insulin resistance and/or Type 2 Diabetes
A fasting blood sugar level of ≥ 7.0 mmol / L (126 mg/dL) is used in the general diagnosis of diabetes. [17] There are no clear guidelines for the diagnosis of LADA, but the criteria often used are that the patient should develop the disease in adulthood, not need insulin treatment for the first 6 months after diagnosis and have autoantibodies in the blood.
Diabetes mellitus type 1 [2] Pancreatic beta cell proteins (possibly insulin, glutamate decarboxylase) Insulitis, beta cell destruction Granulomas [3] Various, depending on underlying disease Walled-off lesion containing macrophages and other cells Some peripheral neuropathies: Schwann cell antigen Neuritis, paralysis: Hashimoto's thyroiditis [2]
Commonly affected areas in autoimmune diseases include blood vessels, connective tissues, joints, muscles, red blood cells, skin, and endocrine glands such as the thyroid gland (in diseases like Hashimoto's thyroiditis and Graves' disease) and the pancreas (in type 1 diabetes).
Diabetes mellitus type 1: Pancreas: Anti-insulin, anti-IA-2, anti-GAD, anti-ZnT8 antibodies Confirmed 1.6 per 1,000 [78] Endometriosis: Endometrium: Anti-endometrial antibodies Probable 6-10% of women of reproductive age [79] Graves' disease: Thyroid gland: TSI, TPO, TG antibodies Confirmed 1.2% of the population [80] Hashimoto's thyroiditis ...
Diabetes mellitus cases due to a known defect are classified separately. Type 2 diabetes is the most common type of diabetes mellitus accounting for 95% of diabetes. [2] Many people with type 2 diabetes have evidence of prediabetes (impaired fasting glucose and/or impaired glucose tolerance) before meeting the criteria for type 2 diabetes. [60]
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