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Activin is produced in the gonads, pituitary gland, placenta, and other organs: In the ovarian follicle, activin increases FSH binding and FSH-induced aromatization. It participates in androgen synthesis enhancing LH action in the ovary and testis. In the male, activin enhances spermatogenesis.
Follistatin, also known as activin-bindings protein, is a protein that in humans is encoded by the FST gene. [ 5 ] [ 6 ] Follistatin is an autocrine glycoprotein that is expressed in nearly all tissues of higher animals.
Elevated FSH receptor levels have been detected in the endothelia of tumor vasculature in a very wide range of solid tumors. FSH binding is thought to upregulate neovascularization via at least two mechanisms – one in the VEGF pathway, and the other VEGF independent – related to the development of umbilical vasculature when physiological.
3624 16323 Ensembl ENSG00000122641 ENSMUSG00000041324 UniProt P08476 Q04998 RefSeq (mRNA) NM_002192 NM_008380 RefSeq (protein) NP_002183 NP_002183.1 NP_032406 Location (UCSC) Chr 7: 41.67 – 41.71 Mb Chr 13: 16.19 – 16.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Inhibin, beta A, also known as INHBA, is a protein which in humans is encoded by the INHBA gene. INHBA is a ...
inhibin and activins, secreted after puberty, work together to regulate FSH secretion; androgen-binding protein (also called testosterone-binding globulin) increases testosterone concentration in the seminiferous tubules to lightly stimulate spermatogenesis; estradiol - an aromatase converts testosterone to 1,7-beta-estradiol to direct ...
The transforming growth factor beta (TGFβ) receptors are a family of serine/threonine kinase receptors involved in TGF beta signaling pathway.These receptors bind growth factor and cytokine signaling proteins in the TGF-beta family such as TGFβs (TGFβ1, TGFβ2, TGFβ3), bone morphogenetic proteins (BMPs), growth differentiation factors (GDFs), activin and inhibin, myostatin, anti-Müllerian ...
Today's NYT Connections puzzle for Thursday, February 13, 2025The New York Times
The follicle-stimulating hormone receptor or FSH receptor (FSHR) is a transmembrane receptor that interacts with the follicle-stimulating hormone (FSH) and represents a G protein-coupled receptor (GPCR). Its activation is necessary for the hormonal functioning of FSH. FSHRs are found in the ovary, testis, and uterus.