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Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections. [1] Other uses include for middle ear infections and travelers' diarrhea. [1] With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS. [1] [2] It is taken orally (swallowed by mouth). [1]
The synergy between trimethoprim and sulfamethoxazole was first described in the late 1960s. [25] [26] [27] Trimethoprim and sulfamethoxazole have a greater effect when given together than when given separately, because they inhibit successive steps in the folate synthesis pathway. They are given in a one-to-five ratio in their tablet ...
DSPD is frequently misdiagnosed or dismissed. It has been named as one of the sleep disorders most commonly misdiagnosed as a primary psychiatric disorder. [34] DSPD is often confused with psychophysiological insomnia; depression; psychiatric disorders such as schizophrenia, ADHD or ADD; other sleep disorders; or school refusal.
Sleep inversion may be a symptom of elevated blood ammonia levels [2] and is often an early symptom of hepatic encephalopathy. [3] Sleep inversion is a feature of African trypanosomiasis, after which the disease takes its common name, "African sleeping sickness"; [4] sleep-wake cycle disturbances are the most common indication that the disease has reached the stage where infection spreads into ...
Hypersomnia can be secondary to disorders such as clinical depression, multiple sclerosis, encephalitis, epilepsy, or obesity. [17] Hypersomnia can also be a symptom of other sleep disorders, like sleep apnea. [17] It may occur as an adverse effect of taking certain medications, of withdrawal from some medications, or of substance use. [17]
Insufficient quality or quantity of night time sleep [5] Obstructive sleep apnea [6] Misalignments of the body's circadian pacemaker with the environment (e.g., jet lag, shift work, or other circadian rhythm sleep disorders) [7] Another underlying sleep disorder, such as narcolepsy, sleep apnea, [8] idiopathic hypersomnia, or restless legs syndrome