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Molecular mimicry is thus occurring between two recognized peptides that have similar antigenic surfaces in the absence of primary sequence homology. For example, specific single amino acid residues such as cysteine (creates di-sulfide bonds), arginine or lysine (form multiple hydrogen bonds), could be essential for T cell cross-reactivity.
Chemical mimicry (or molecular mimicry) is a type of biological mimicry involving the use of chemicals to dupe an operator. A chemical mimic dupes an operator (e.g. a predator) by showing an adaptive chemical resemblance to an object of its environment and as a consequence receives selective advantage. [ 1 ]
Molecular mimicry may be particularly relevant to the tolerance breakdown linked to autoimmune neuropathies. The process known as "molecular mimicry" occurs when an infectious organism that shares epitopes from its host's afflicted tissue triggers an immune response in the host. However, only a small number of convincingly identified specific ...
[5] [19] The molecular mimicry hypothesis is a proposed mechanism for PANDAS: [13] this hypothesis is that antigens on the cell wall of the streptococcal bacteria are similar in some way to the proteins of the heart valve, joints, or brain.
Normally, T cell activation is triggered by the presentation of bacterial antigens. In RHD, molecular mimicry results in incorrect T cell activation, and these T lymphocytes can go on to activate B cells, which will begin to produce self-antigen-specific antibodies. This leads to an immune response attack mounted against tissues in the heart ...
Diabetes, a condition where blood glucose levels cannot be controlled, affects more than 10% of the adult population worldwide, and more than 90% of those have type 2 diabetes.
Milos Uzan scored a season-high 19 points to help No. 6 Houston rally for a 62-58 victory over No. 13 Arizona in Big 12 play on Saturday afternoon at Tucson, Ariz.
WASHINGTON (Reuters) -U.S. President Donald Trump is considering merging the U.S. Agency for International Development with the State Department to boost its efficiency and ensure its spending is ...