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A series of studies, principally from the Mayo Clinic, have indicated that patients with an abnormal free kappa to free lambda ratio have an increased risk of progression to active myeloma from precursor conditions including monoclonal gammopathy of undetermined significance (MGUS), [32] [33] smouldering myeloma [34] and solitary plasmacytoma ...
Once set, light chain class remains fixed for the life of the B lymphocyte. In a healthy individual, the total kappa-to-lambda ratio is roughly 2:1 in serum (measuring intact whole antibodies) or 1:1.5 if measuring free light chains, with a highly divergent ratio indicative of neoplasm. The free light chain ratio ranges from 0.26 to 1.65. [1]
10–39 years: 54 [23] 110 [23] mg/dL ... million/mm 3: Female: 3.5, [14] 3.8, ... kappa/lambda ratio: 0.26 [169] 1.65 [169] (unitless) Other enzymes and proteins
Late Devonian: 375 million years ago, 75% of species lost, including most trilobites; End Permian, The Great Dying: 251 million years ago, 96% of species lost, including tabulate corals, and most trees and synapsids; End Triassic: 200 million years ago, 80% of species lost, including all conodonts
The Silurian hypothesis is a thought experiment, [1] which assesses modern science's ability to detect evidence of a prior advanced civilization, perhaps several million years ago. The most probable clues for such a civilization could be carbon , radioactive elements or temperature variation.
A researcher claims to have found evidence of humans in Chesapeake Bay over 22,000 years ago. ... White Sands National Park date human activity in the area to between 21,000 and 23,000 years ago ...
This is an accepted version of this page This is the latest accepted revision, reviewed on 26 January 2025. Scientific projections regarding the far future Several terms redirect here. For other uses, see List of numbers and List of years. Artist's concept of the Earth 5–7.5 billion years from now, when the Sun has become a red giant While the future cannot be predicted with certainty ...
It is estimated by J. Lawrence Angel [15] that the average life span of hominids on the African savanna between 4,000,000 and 200,000 years ago was 20 years. This means that the population would be completely renewed about five times per century, [ citation needed ] assuming that infant mortality has already been accounted for [ clarification ...