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A biosafety level (BSL), or pathogen/protection level, is a set of biocontainment precautions required to isolate dangerous biological agents in an enclosed laboratory facility. The levels of containment range from the lowest biosafety level 1 (BSL-1) to the highest at level 4 (BSL-4).
The levels of containment range from the lowest biosafety level 1 (BSL-1) to the highest at level 4 (BSL-4). In the United States, the Centers for Disease Control and Prevention (CDC) have specified these levels. [8] In the European Union, the same biosafety levels are defined in a directive. [9]
Biosafety level refers to the stringency of biocontainment precautions deemed necessary by the Centers for Disease Control and Prevention (CDC) for laboratory work with infectious materials. Typically, institutions that experiment with or create potentially harmful biological material will have a committee or board of supervisors that is in ...
Not all select agents require BSL-4 handling, namely select bacteria and toxins, but most select agent viruses do (with the notable exception of SARS-CoV-1 which can be handled in BSL3). Many non-select agent viruses are often handled in BSL-4 according to facility SOPs or when dealing with new viruses closely related to viruses that require BSL-4.
BSL-4 cabinets and "Suit Laboratories" have special engineering and design features to prevent hazardous microorganisms from being disseminated into the outside environment. These biosafety suites , where PPPSs are used, are suites of laboratory rooms which are essentially equivalent to large Class III biosafety cabinets in which the interiors ...
A biosafety cabinet (BSC)—also called a biological safety cabinet or microbiological safety cabinet—is an enclosed, ventilated laboratory workspace for safely working with materials contaminated with (or potentially contaminated with) pathogens requiring a defined biosafety level.
NEIDL is one of only 13 operational or planned biosafety level 4 (BSL-4) laboratories in the United States. NEIDL's current director is Nancy Sullivan, ScD . She previously served as the chief of the Biosecurity Research Section at the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases (NIAID) in the National ...
A Senegalese epidemiologist was infected with Ebola at a BSL-4 laboratory in Kailahun, Sierra Leone. The World Health Organization later shut down the lab. [62] 2014 Dengue South Korea A 30-year-old female laboratory worker in South Korea working at a BSL-2 was infected with Dengue through a needlestick injury. [63] 2016 Zika virus: United States