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A hormonal intrauterine device (IUD), also known as an intrauterine system (IUS) with progestogen and sold under the brand name Mirena among others, is an intrauterine device that releases a progestogenic hormonal agent such as levonorgestrel into the uterus. [2]
Misoprostol by mouth is the least effective treatment for producing complete abortion in a period of 24 hours due to the liver's first-pass effect which reduces the bioavailability of the misoprostol. Vaginal and sublingual routes result in greater efficacy and extended duration of action because these routes of administration allow the drug to ...
Mirena [30] Skyla [31] Liletta [32] Kyleena [33] Hormone (total in device) None 52 mg levonorgestrel 13.5 mg levonorgestrel 52 mg levonorgestrel 19.5 mg levonorgestrel Initial amount released None 20 μg/day 14 μg/day 18.6 μg/day 16 μg/day Approved effectiveness 10 years (12 years) 5 years (10 years) 3 years 3 years (5 years) 5 years
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The typical dosage is either 1.5 mg taken once or 0.75 mg taken 12–24 hours apart. [37] The effectiveness in both methods is similar. [ 37 ] The most widely used form of oral emergency contraception is the progestin-only pill , which contains a 1.5 mg dosage of levonorgestrel. [ 36 ]
The approved dosing regimen is 200 mg of mifepristone taken by mouth (swallowed). 24 to 48 hours after taking mifepristone, 800 mcg (micrograms) of misoprostol is taken buccally (in the cheek pouch), at a location appropriate for the patient. [22] [108] [109] [110]
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