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2. Epigenetic effects of smoking - Wikipedia

   en.wikipedia.org/wiki/Epigenetic_effects_of_smoking

   Histone modifications are another epigenetic phenomenon known to be affected by smoking. Cigarette smoke has been observed to globally alter histone modifications near the promoter regions of pro-inflammatory genes, mainly through an overall increase in acetylation. [3] [5] Cigarette smoke can alter histone acetylation through a number of pathways.

3. Nicotine - Wikipedia

   en.wikipedia.org/wiki/Nicotine

   Nicotine and cigarette smoke both induce the expression of liver enzymes (e.g., certain cytochrome P450 proteins) which metabolize drugs, leading to the potential for alterations in drug metabolism. [79] Smoking cessation may decrease the metabolism of acetaminophen, beta-blockers, caffeine, oxazepam, pentazocine, propoxyphene, theophylline ...

4. Cigarette smoking for weight loss - Wikipedia

   en.wikipedia.org/wiki/Cigarette_Smoking_for...

   As nicotine is an appetite suppressant and smokers expend more energy, weight gain due to smoking cessation is generally attributed to increased calorific intake and a slowed metabolic rate. Weight gain can be a deterrent in the smoking cessation process, even if many smokers did not smoke for weight control purposes. [ 31 ]

5. Why it's so hard to quit smoking — and how to boost ... - AOL

   www.aol.com/lifestyle/why-hard-quit-smoking...

   Here’s what you need to know about how nicotine reliance starts — and how to increase the odds of ending it for good. How nicotine works. ... does not aid in smoking cessation. And many people ...

6. Effects of nicotine on human brain development - Wikipedia

   en.wikipedia.org/wiki/Effects_of_nicotine_on...

   How does the nicotine in e-cigarettes affect the brain? [6] Until about age 25, the brain is still growing. [6] Each time a new memory is created or a new skill is learned, stronger connections – or synapses – are built between brain cells. [6] Young people's brains build synapses faster than adult brains. [6]

7. Microdosing nicotine: Could it actually be good for your ...

   www.aol.com/lifestyle/microdosing-nicotine-could...

   "Nicotine use can increase the risk of both cancer and cardiovascular disease," he says. "Even low levels of nicotine can alter blood pressure and heart rate, which in the long run have adverse ...

8. CYP2A6 - Wikipedia

   en.wikipedia.org/wiki/CYP2A6

   Cytochrome P450 2A6 (abbreviated CYP2A6) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. CYP2A6 is the primary enzyme responsible for the oxidation of nicotine and cotinine. It is also involved in the metabolism of several pharmaceuticals, carcinogens, and a ...

9. Smoking cessation - Wikipedia

   en.wikipedia.org/wiki/Smoking_cessation

   Possible reasons for this phenomenon include nicotine's ability to increase energy metabolism or nicotine's effect on peripheral neurons. [202] The U.S. Department of Health and Human Services guideline suggests that sustained-release bupropion, nicotine gum, and nicotine lozenge be used "to delay weight gain after quitting."