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Doxylamine succinate is the active ingredient in many over-the-counter sleep aids branded under various names. Doxylamine succinate and pyridoxine (Vitamin B6) are the ingredients of Diclegis, approved by the FDA in April 2013 becoming the only drug approved for morning sickness [46] with a class A safety rating for pregnancy (no evidence of risk).
All medications within the NyQuil imprint contain sedating antihistamines, hypnotics, and/or alcohol; they are intended to be taken before sleep. Its daytime counterpart is antihistamine-free DayQuil, formulated to avoid drowsiness. NyQuil is also used as a sleep aid. [1] NyQuil was first marketed in the United States in 1966. [2] [3]
Zyrtec. Zyrtec is a brand name for the drug cetirizine. ... “While antihistamines [like Zyrtec and Claritin] can help with sneezing, itching and runny nose, first line therapy for relief of ...
In July 1975, the J. B. Williams Co. began marketing Sominex 2. [37] On November 24, 1975, Attorney General Evelle J. Younger filed suit on behalf of the State of California against Williams Co., stating that the product did not warn against use by pregnant or nursing women or persons with asthma or COPD, nor did it notify consumers that it should not be used in conjunction with alcohol. [38]
Doses of hydroxyzine hydrochloride used for sleep range from 25 to 100 mg. [15] [16] [17] As with other antihistamine sleep aids, hydroxyzine is usually only prescribed for short term or "as-needed" use since tolerance to the CNS (central nervous system) effects of hydroxyzine can develop in as little as a few days.
Adverse drug reactions are most commonly associated with the first-generation H 1-antihistamines. This is due to their relative lack of selectivity for the H 1-receptor and their ability to cross the blood–brain barrier. The most common adverse effect is sedation; this "side-effect" is utilized in many OTC sleeping-aid