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ORF1ab (also ORF1a/b) refers collectively to two open reading frames (ORFs), ORF1a and ORF1b, that are conserved in the genomes of nidoviruses, a group of viruses that includes coronaviruses. The genes express large polyproteins that undergo proteolysis to form several nonstructural proteins with various functions in the viral life cycle ...
In virology, a nonstructural protein is a protein encoded by a virus but that is not part of the viral particle. [1] They typically include the various enzymes and transcription factors the virus uses to replicate itself, such as a viral protease (3CL/nsp5, etc.), an RNA replicase or other template-directed polymerases, and some means to control the host.
The Epsilon variant or lineage B.1.429, also known as CAL.20C [158] or CA VUI1, [159] 21C [75] or 20C/S:452R, [97] is defined by five distinct mutations (I4205V and D1183Y in the ORF1ab gene, and S13I, W152C, L452R in the spike protein's S-gene), of which the L452R (previously also detected in other unrelated lineages) was of particular concern.
Omicron (B.1.1.529) is a variant of SARS-CoV-2 first reported to the World Health Organization (WHO) by the Network for Genomics Surveillance in South Africa on 24 November 2021.
Human coronavirus OC43 [1] (HCoV-OC43) is a member of the species Betacoronavirus 1, which infects humans and cattle. [2] [3] The infecting coronavirus is an enveloped, positive-sense, single-stranded RNA virus that enters its host cell by binding to the N-acetyl-9-O-acetylneuraminic acid receptor. [4]
LDV has a genome that consists of single stranded positive sense RNA that is 14.1kb long. The genome is dominated by two large open reading frames, ORF1a and ORF1ab; these code for two polyproteins, PP1a and PP1ab. These polyproteins are thought to be cleaved into 12 products.
This page was last edited on 15 November 2021, at 08:25 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
The name "betacoronavirus" is derived from Ancient Greek βῆτα (bē̂ta, "the second letter of the Greek alphabet"), and κορώνη (korṓnē, “garland, wreath”), meaning crown, which describes the appearance of the surface projections seen under electron microscopy that resemble a solar corona.