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The rate of cancer recurrence is determined by many factors, including age, sex, cancer type, treatment duration, stage of advancement, grade of original tumor, and cancer-specific risk factors. [2] [3] [4] If recurrent cancer has already moved to other body parts or has developed chemo-resistance then it may be more aggressive than original ...
Staging breast cancer is the initial step to help physicians determine the most appropriate course of treatment. As of 2016, guidelines incorporated biologic factors, such as tumor grade, cellular proliferation rate, estrogen and progesterone receptor expression, human epidermal growth factor 2 (HER2) expression, and gene expression profiling into the staging system.
Invasive carcinoma NST accounts for half of all breast cancer diagnoses in women and is the most common type of invasive breast cancer. It is also the most commonly diagnosed form of male breast cancer. Invasive carcinoma NST is classified by its microscopic, molecular, and genetic features.
IORT is typically a component in the multidisciplinary treatment of locally advanced and recurrent cancer, in combination with external beam radiation, surgery, and chemotherapy. As a growing trend in recent years, IORT can also be used in earlier stage cancers such as prostate and breast cancer.
The combined effects of radiation and breast cancer surgery can in particular lead to complications such as breast fibrosis, secondary lymphoedema (which may occur in the arm, the breast or the chest, in particular after axillary lymph node dissection [5] [6]), breast asymmetry, and chronic/recurrent breast cellulitis, each of these having long ...
In addition, there are several important misconceptions regarding breast-conservation surgery for patients and clinicians to keep in mind. [8] In appropriately selected patients, mastectomy and breast-conserving surgery have equivalent survival rates. Undergoing mastectomy does not eliminate the risk for recurrent or new cancer.
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