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Axon guidance (also called axon pathfinding) is a subfield of neural development concerning the process by which neurons send out axons to reach their correct targets. Axons often follow very precise paths in the nervous system, and how they manage to find their way so accurately is an area of ongoing research.
Established collateral branches, like the main axon, exhibit a growth cone and develop independently of the main axon tip. Overall, axon elongation is the product of a process known as tip growth. In this process, new material is added at the growth cone while the remainder of the axonal cytoskeleton remains stationary.
In neuroscience, the axolemma (from Greek lemma 'membrane, envelope', and 'axo-' from axon [1]) is the cell membrane of an axon, [1] the branch of a neuron through which signals (action potentials) are transmitted. The axolemma is a three-layered, bilipid membrane. Under standard electron microscope preparations, the structure is approximately ...
A reconstruction of a pyramidal cell. Soma and dendrites are labeled in red, axon arbor in blue. (1) Soma, (2) Basal dendrite, (3) Apical dendrite, (4) Axon, (5) Collateral axon. One of the main structural features of the pyramidal neuron is the conic shaped soma, or cell body, after which the neuron is named.
An axon can divide into many branches called telodendria (Greek for 'end of tree'). At the end of each telodendron is an axon terminal (also called a terminal bouton or synaptic bouton, or end-foot). [20] Axon terminals contain synaptic vesicles that store the neurotransmitter for release at the synapse. This makes multiple synaptic connections ...
The Schaffer collateral is located between the CA3 region and CA1 region in the hippocampus. Schaffer collaterals are the axons of pyramidal cells that connect two neurons (CA3 and CA1) and transfer information from CA3 to CA1. [5] [6] The entorhinal cortex sends the main input to the dentate gyrus (perforant pathway).
They send an inhibitory axon to synapse with the cell body of the initial alpha neuron and/or an alpha motor neuron of the same motor pool. In this way, the Renshaw cell action represents a negative feedback mechanism. A Renshaw cell may be supplied by more than one alpha motor neuron collateral and it may synapse on multiple motor neurons.
All of these sensations travel along the same general pathways towards the brain. One pathway— dorsal column–medial lemniscus pathway —begins with sensation from the periphery being sent via afferent nerve fiber of the dorsal root ganglion (first order neuron) through the spinal cord to the dorsal column nuclei (second order neuron) in ...