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FISH can be used to measure the number of copies of the gene which are present and is thought to be more reliable than immunohistochemistry. [47] It usually uses chromosome enumeration probe 17 (CEP17) to count the amount of chromosomes. Hence, the HER2/CEP17 ratio reflects any amplification of HER2 as compared to the number of chromosomes.
Date: 12 August 2019: Source: Own work, using following image: . Image source: Halilovic A, Verweij DI, Simons A, Stevens-Kroef MJPL, Vermeulen S, Elsink J (2019)."HER2, chromosome 17 polysomy and DNA ploidy status in breast cancer; a translational study.
Date: 8 May 2012: Source: Jiang H, Bai X, Zhang C, Zhang X (2012). "Evaluation of HER2 gene amplification in breast cancer using nuclei microarray in situ hybridization.Int J Mol Sci 13 (5): 5519-5527.
It is a well-established technique for HER-2/neu amplification detection even though it is sometimes reported to be less effective than FISH. [27] In this technique, one probe binds the reference which, in the case of HER-2/neu amplification detection, is CEN17 (the centromere of chromosome 17) while the other probe binds the target sequence ...
Multiplexed error-robust fluorescence in situ hybridization [24] is a highly multiplexed version of smFISH. It uses combinatorial labeling, followed by imaging, and then error-resistant encoding [25] to capture a high number of RNA molecules and spatial localization within the cell. The capture of a large number of RNA molecules enables ...
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