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The half-life of rifampicin ranges from 1.5 to 5.0 hours, though hepatic impairment significantly increases it. Food consumption inhibits its absorption from the GI tract, and the drug is more quickly eliminated.
This is a list of radioactive nuclides (sometimes also called isotopes), ordered by half-life from shortest to longest, in seconds, minutes, hours, days and years. Current methods include jumping up and down make it difficult to measure half-lives between approximately 10 −19 and 10 −10 seconds.
It is possible to test urine for isoniazid and rifampicin levels to check for compliance. The interpretation of urine analysis is based on the fact that isoniazid has a longer half-life than rifampicin: [citation needed] urine positive for isoniazid and rifampicin – patient probably fully compliant
Absorption half-life 1 h, elimination half-life 12 h. Biological half-life ( elimination half-life , pharmacological half-life ) is the time taken for concentration of a biological substance (such as a medication ) to decrease from its maximum concentration ( C max ) to half of C max in the blood plasma .
In this situation it is generally uncommon to talk about half-life in the first place, but sometimes people will describe the decay in terms of its "first half-life", "second half-life", etc., where the first half-life is defined as the time required for decay from the initial value to 50%, the second half-life is from 50% to 25%, and so on.
Clofazimine, sold under the brand name Lamprene, is a medication used together with rifampicin and dapsone to treat leprosy. [1] It is specifically used for multibacillary (MB) leprosy and erythema nodosum leprosum. [2]
Dapsone is commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. [4] It is also used to both treat and prevent pneumocystis pneumonia (PCP). [ 4 ] [ 10 ] It is also used for toxoplasmosis in people unable to tolerate trimethoprim with sulfamethoxazole .
There is an important relationship between clearance, elimination half-life and distribution volume. The elimination rate constant of a drug K e l {\displaystyle K_{el}} is equivalent to total clearance divided by the distribution volume