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It often takes on the classical "target lesion" appearance, [7] with a pink-red ring around a pale center. Resolution within 7–10 days is the norm. Individuals with persistent (chronic) erythema multiforme will often have a lesion form at an injury site, e.g. a minor scratch or abrasion, within a week.
Target lesions are the typical lesions of erythema multiforme, in which a vesicle is surrounded by an often hemorrhagic maculopapule. Erythema multiforme is often self-limited, of acute onset, resolves in three to six weeks, and has a cyclical pattern. Its lesions are multiform (polymorphous) and include macules, papules, vesicles, and bullae.
Erythema multiforme (EM) is usually a reaction of the skin and mucous membranes that occurs suddenly. [1] It appears as a symmetrical rash and may include the mucous membrane lesions. This means that the body is sensitive to something that causes the skin and mucous membranes to react. The more common mild form is refer to as EM minor.
Targetoid lesions are distinguished by a concentric ring-like appearance that resembles a target or bull's-eye. Classic target lesions with three concentric zones are commonly associated with erythema multiforme (a type of skin rash), while targetoid lesions with only two zones can appear in various dermatological conditions.
Generalized bullous fixed drug eruption (GBFDE) most commonly refers to a drug reaction in the erythema multiforme group. [3]: 129 These are uncommon reactions to medications, with an incidence of 0.4 to 1.2 per million person-years for toxic epidermal necrolysis and 1.2 to 6.0 per million person-years for Stevens–Johnson syndrome.
"Erythema migrans is the only manifestation of Lyme disease in the United States that is sufficiently distinctive to allow clinical diagnosis in the absence of laboratory confirmation." [8] [9] Often, but not always, mentions of a target lesion (bull's-eye lesion) are talking about erythema migrans. However, the appearance of erythema migrans ...
In dermatology, erythema multiforme major is a form of rash with skin loss or epidermal detachment. The term "erythema multiforme majus" is sometimes used to imply a bullous (blistering) presentation. [2] According to some sources, there are two conditions included on a spectrum of this same disease process: Stevens–Johnson syndrome (SJS)
Smooth red-topped small papules which merge into plaques, small fluid-filled blisters (papulovesicles) [2] and less commonly target-shaped lesions which look like erythema multiforme may be visible. [5] In addition, it may occur in other parts of the body in some people treated for inflammatory skin diseases with phototherapy. [2]