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Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. [1] Professor Marshall Urist and Professor Hari Reddi discovered their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body.
Type 1 contains a glycine-serine-rich domain to be phosphorylated by type 2 kinase domain, initiating the signaling transduction pathway of the SMAD signaling cascade. [3] The wrist epitope motif on BMP-2 has a high-affinity binding site for BMPR-IA. The knuckle epitope motif on BMP-2 has a low-affinity binding site for BMPR-II. [4]
BMP-2 like other bone morphogenetic proteins, [6] plays an important role in the development of bone and cartilage. It is involved in the hedgehog pathway , TGF beta signaling pathway , and in cytokine -cytokine receptor interaction.
12155 Ensembl ENSG00000130385 ENSMUSG00000023279 UniProt O95972 Q9Z0L4 RefSeq (mRNA) NM_005448 NM_009757 RefSeq (protein) NP_005439 NP_033887 Location (UCSC) Chr X: 50.91 – 50.92 Mb Chr X: 6.23 – 6.23 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Bone morphogenetic protein 15 (BMP-15) is a protein that in humans is encoded by the BMP15 gene. It is involved in folliculogenesis ...
BMPR2 is expressed on both human and animal granulosa cells, and is a crucial receptor for bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9). ). These two protein signaling molecules and their BMPR2-mediated effects play an important role in follicle development in preparation for ovulatio
12166 Ensembl ENSG00000107779 ENSMUSG00000021796 UniProt P36894 P36895 RefSeq (mRNA) NM_004329 NM_009758 RefSeq (protein) NP_004320 NP_033888 Location (UCSC) Chr 10: 86.76 – 86.93 Mb Chr 14: 34.13 – 34.23 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The bone morphogenetic protein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the BMPR1A gene ...