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Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
This is thanks to an enzyme called phosphodiesterase type 5 (PDE5). Viagra inhibits PDE5 and acts as a vasodilator (something that dilates blood vessels and increases blood flow).
Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and increased ...
The inhibitor is highly selective for the PDE5 family. [22] Sildenafil is a prototype of PDE5 inhibitors that Pfizer launched as Viagra. It was approved by the Food and Drug Administration (FDA) in 1998 as the first oral medicine for erectile dysfunction. Later, in the year 2005, it was approved for the treatment of pulmonary arterial ...
Viagra could lead to more serious side effects, such as: Priapism (a painful, long-lasting arousal) ... and a healthcare professional will explain that phosphodiesterase type 5 inhibitors aren’t ...
Sildenafil (Viagra) Tadalafil (Cialis) Vardenafil (Levitra) Avanafil (Stendra) All of these meds belong to a class of drugs called phosphodiesterase type 5 inhibitors, or PDE5 inhibitors. They ...