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  2. Milnacipran - Wikipedia

    en.wikipedia.org/wiki/Milnacipran

    During its development for fibromyalgia, milnacipran was evaluated utilizing a composite responder approach.To be considered as a responder for the composite ‘treatment of fibromyalgia’ endpoint, each patient had to show concurrent and clinically meaningful improvements in pain, physical function, and global impression of disease status.

  3. Tianeptine - Wikipedia

    en.wikipedia.org/wiki/Tianeptine

    Tianeptine also has anticonvulsant and analgesic effects, [31] and a clinical trial in Spain that ended in January 2007 has shown that tianeptine is effective in treating pain due to fibromyalgia. [32] Tianeptine has been shown to have efficacy with minimal side effects in the treatment of attention-deficit hyperactivity disorder. [33]

  4. Fibromyalgia - Wikipedia

    en.wikipedia.org/wiki/Fibromyalgia

    The use of medication in the treatment of fibromyalgia is debated, [18] [19] although antidepressants can improve quality of life. [20] Other medications commonly considered helpful in managing fibromyalgia include serotonin–norepinephrine reuptake inhibitors, nonsteroidal anti-inflammatory drugs, and muscle relaxants. [21]

  5. Cyclobenzaprine - Wikipedia

    en.wikipedia.org/wiki/Cyclobenzaprine

    A 2004 review found benefit for fibromyalgia symptoms, with a reported number needed to treat of 4.8 (meaning that 1 person out of every 4.8 benefits from treatment) for pain reduction, but no change in fatigue or tender points. [36] A 2009 Cochrane review found insufficient evidence to justify its use in myofascial pain syndrome. [37]

  6. Amidrine - Wikipedia

    en.wikipedia.org/wiki/Amidrine

    Paracetamol, also known as acetaminophen, is a common over-the-counter pain reliever and fever reducer. Dichloralphenazone is a prodrug of two pharmacologically distinct agents: the sedative agent, chloral hydrate , as well as antipyrine , a non-steroidal anti-inflammatory drug that works to decrease inflammation .

  7. Anticonvulsant - Wikipedia

    en.wikipedia.org/wiki/Anticonvulsant

    Therefore, almost all new epilepsy drugs are initially approved only as adjunctive (add-on) therapies. Patients whose epilepsy is uncontrolled by their medication (i.e., it is refractory to treatment) are selected to see if supplementing the medication with the new drug leads to an improvement in seizure control.

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