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Active transport is usually associated with accumulating high concentrations of molecules that the cell needs, such as ions, glucose and amino acids. Examples of active transport include the uptake of glucose in the intestines in humans and the uptake of mineral ions into root hair cells of plants.
Intracellular transport is the movement of vesicles and substances within a cell. Intracellular transport is required for maintaining homeostasis within the cell by responding to physiological signals. [1] Proteins synthesized in the cytosol are distributed to their respective organelles, according to their specific amino acid’s sorting ...
Lipid A is an endotoxin and so loss of MsbA from the cell membrane or mutations that disrupt transport results in the accumulation of lipid A in the inner cell membrane resulting to cell death. It is a close bacterial homolog of P-glycoprotein (Pgp) by protein sequence homology and has overlapping substrate specificities with the MDR-ABC ...
In cellular biology, membrane transport refers to the collection of mechanisms that regulate the passage of solutes such as ions and small molecules through biological membranes, which are lipid bilayers that contain proteins embedded in them. The regulation of passage through the membrane is due to selective membrane permeability – a ...
The sodium–potassium pump (a type of P-type ATPase) is found in many cell (plasma) membranes and is an example of primary active transport.Powered by ATP, the pump moves sodium and potassium ions in opposite directions, each against its concentration gradient.
Diseases caused by ion channel malfunctions include cystic fibrosis where the channel for the chloride ion will not open or is missing in the cells of the lungs, intestine, pancreas, liver and skin. The cells can no longer regulate salt and water concentrations resulting in the symptoms typical of the disease.
Transcytosis (also known as cytopempsis) [1] is a type of transcellular transport in which various macromolecules are transported across the interior of a cell.Macromolecules are captured in vesicles on one side of the cell, drawn across the cell, and ejected on the other side.
I-cell disease is an autosomal recessive disorder caused by a deficiency of GlcNAc phosphotransferase, which phosphorylates mannose residues to mannose-6-phosphate on N-linked glycoproteins in the Golgi apparatus within cells.