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In vitro testing demonstrated that AOH1996 inhibited the growth and induced cell cycle arrest and apoptotic cell death in a wide variety of cancer cell lines, but had no effect on several normal, nonmalignant cell types. [6] [7] In mouse and dog animal models, there were no observed side effects or toxicity even at six times the effective dose. [3]
Cysteamine and methionine have also been used to prevent hepatotoxicity, [69] although studies show that both are associated with more adverse effects than acetylcysteine. [20] Additionally, acetylcysteine has been shown to be a more effective antidote, particularly in patients presenting greater than 8 hours post-ingestion [ 70 ] and for those ...
Research has found that acetylcysteine may have otoprotective properties and could potentially be useful for preventing hearing loss and tinnitus in some cases. [78] [79] A 2011 study showed that N-acetylcysteine may protect the human cochlea from subclinical hearing loss caused by loud noises such as impulse noise. [80]
Half the dogs received bedinvetmab and half the dogs received a sterile saline injection every 28 days for a total of three doses. [5] Before treatment and on various days throughout the study, owners used the Canine Brief Pain Inventory (CBPI) assessment tool to measure the severity of the dog's pain and the degree to which the pain interfered ...
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In most cases, appropriate treatment protocols cause few side effects, but white blood cell counts must be monitored. Allogeneic and autologous stem cell transplantations (as is commonly done in humans) have recently been shown to be a possible treatment option for dogs. [19] Most of the basic research on transplantation biology was generated ...
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