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This is the list of Schedule I controlled substances in the United States as defined by the Controlled Substances Act. [1] The following findings are required for substances to be placed in this schedule: [2]
Tier 2 banding is also incorporated into the NIOSH OEB e-tool but can take hours instead of minutes to complete for a given chemical. However, the resulting band is considered more robust than a Tier 1 band due to the in-depth retrieval of published data. [7] NIOSH recommends users complete at least the Tier 2 process to produce reliable OEBs.
It also maintains List I of chemicals and List II of chemicals, which contain chemicals that are used to manufacture the controlled substances/illicit drugs. The list is designated within the Controlled Substances Act [1] but can be modified by the U.S. Attorney General as illegal manufacturing practices change.
NIOSH was created by the Occupational Safety and Health Act of 1970 [27] and began operating in May 1971. [25] It was originally part of the Health Services and Mental Health Administration, and was transferred into what was then called the Center for Disease Control (CDC) in 1973. [27] NIOSH's initial headquarters were located in Rockville ...
Genotoxicity might involve carcinogenicity, the ability to cause cancer in animal models, humans or both; teratogenicity, which is the ability to cause defects on fetal development or fetal malformation; and lastly hazardous drugs are known to have the potential to cause fertility impairment, which is a major concern for most clinicians. [1 ...
National Institute for Occupational Safety and Health (NIOSH) RELs are designed to protect the health and well-being of workers by recommending safe exposure levels. To really use these guidelines well, safety professionals need to understand the recommended exposure levels, how to measure them, and ways to make sure workers aren't exposed to harmful stuff.
The NIOSH definition is the only definition that includes drug vapors. [8] NIOSH considers the containment of vapor extremely important, such that in September 2015, NIOSH issued a Testing Protocol to assess the effectiveness of closed systems. [9] NIOSH developed and tested five CSTDs to assess its "closeness". Two of the five CSTDs tested passed.
Category 1: Substances known to be carcinogenic to humans. Category 2: Substances which should be regarded as if they are carcinogenic to humans. Category 3: Substances which cause concern for humans, owing to possible carcinogenic effects but in respect of which the available information is not adequate for making a satisfactory assessment.