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Antibacterials like dapsone (increases plasma levels of both drugs), methenamine (increased risk of crystalluria) and rifampicin (as it may lead to an increased plasma level of rifampicin and lower plasma levels of trimethoprim) Anticoagulants like warfarin and acenocoumarol — anticoagulant effects of either drug is potentiated by this ...
Its Tmax (or time to reach maximum drug concentration in plasma) occurs 1 to 4 hours after oral administration. The mean serum half-life of sulfamethoxazole is 10 hours. [8] However, the half-life of the drug noticeably increases in people with creatinine clearance rates equal to or less than 30 mL/minute.
This is a list of common β-lactam antibiotics—both administered drugs and those not in clinical use—organized by structural class. Antibiotics are listed alphabetically within their class or subclass by their nonproprietary name. If an antibiotic is a combination drug, both ingredients will be listed.
The overall incidence of adverse drug reactions to sulfa antibiotics is approximately 3%, close to penicillin; [3] hence medications containing sulfonamides are prescribed carefully. Sulfonamide drugs were the first broadly effective antibacterials to be used systemically, and paved the way for the antibiotic revolution in medicine.
Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections. [1] Other uses include for middle ear infections and travelers' diarrhea. [1] With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS.
Bactrim, Septra Sulfonamidochrysoidine (archaic) Prontosil: Tetracyclines(Bs) Demeclocycline: Declomycin: Syphilis, chlamydial infections, Lyme disease, mycoplasmal infections, acne rickettsial infections, malaria [note 1] Gastrointestinal upset; Sensitivity to sunlight; Potential toxicity to mother and fetus during pregnancy
β-Lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused by susceptible organisms. At first, β-lactam antibiotics were mainly active only against gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various gram-negative organisms has increased their usefulness.
Drug fever; Periarteritis nodosa; Hepatic necrosis; Pancreatitis; Myelosuppression; Haemolysis [a] Stevens–Johnson syndrome [b] Drug reaction with eosinophilia and systemic symptoms; Toxic epidermal necrolysis [c] Ataxia [d] Clostridioides difficile colitis; Aseptic meningitis [e] Pseudomembranous colitis; Interstitial nephritis; Fulminant ...