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Template Model: Mad2 already bound to Mad1 is the receptor for free Open Mad2. Open Mad2 binds Cdc20 and then dissociates and can “breed” further Closed Mad2:Cdc20 halt signals. Since unattached kinetochores establish and maintain the SAC, Mad2 is recruited to prevent these misaligned sister chromatids from separating.
10459 71890 Ensembl ENSG00000116670 ENSMUSG00000029003 UniProt Q9UI95 Q9D752 RefSeq (mRNA) NM_001127325 NM_006341 NM_027985 NM_001305420 RefSeq (protein) NP_001120797 NP_006332 NP_001292349 NP_082261 Location (UCSC) Chr 1: 11.67 – 11.69 Mb Chr 4: 148.13 – 148.15 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mitotic spindle assembly checkpoint protein MAD2B is a protein that in ...
56150 Ensembl ENSG00000164109 ENSMUSG00000029910 UniProt Q13257 Q9Z1B5 RefSeq (mRNA) NM_002358 NM_019499 NM_001355624 RefSeq (protein) NP_002349 NP_062372 NP_001342553 Location (UCSC) Chr 4: 120.06 – 120.07 Mb Chr 6: 66.51 – 66.52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 ...
In molecular biology, the HORMA domain (named after the Hop1p, Rev7p and MAD2 proteins) is a protein domain that has been suggested to recognise chromatin states resulting from DNA adducts, double stranded breaks or non-attachment to the spindle and act as an adaptor that recruits other proteins.
66591 Ensembl ENSG00000124688 ENSMUSG00000034509 UniProt Q15013 Q9DCX1 RefSeq (mRNA) NM_014628 NM_001003690 NM_025649 RefSeq (protein) NP_001003690 NP_055443 NP_079925 Location (UCSC) Chr 6: 43.63 – 43.64 Mb Chr 17: 46.46 – 46.46 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse MAD2L1-binding protein is a protein that in humans is encoded by the MAD2L1BP gene. Function The protein ...
The C-Mad2 bound to Mad1 then dimerizes with a second O-Mad2 and catalyzes its closure around Cdc20. This C-Mad2 and Cdc20 complex, the MCC, leaves Mad1 and C-Mad2 at the kinetochore to form another MCC. The MCCs each sequester two Cdc20 molecules to prevent their interaction with the APC/C, thereby maintaining the SAC. [23]
The heterotetramer of Mad1–c-Mad2 is very stable and works as a catalytic receptor for free cytoplasmic o-Mad2. Free o-Mad2 binds to this receptor and changes its conformation to the active closed form. This second c-MAD2 is transferred to Cdc20 with yet unknown mechanism and forms Cdc20–c-Mad2 complex. This complex is an essential ...
12237 Ensembl ENSG00000154473 ENSMUSG00000066979 UniProt O43684 Q9WVA3 RefSeq (mRNA) NM_004725 NM_001007793 NM_009774 NM_001317350 RefSeq (protein) NP_001007794 NP_004716 NP_001304279 NP_033904 Location (UCSC) Chr 10: 123.15 – 123.17 Mb Chr 7: 131.16 – 131.17 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mitotic checkpoint protein BUB3 is a protein that in humans is encoded by ...