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A cell strain is derived either from a primary culture or a cell line by the selection or cloning of cells having specific properties or characteristics which must be defined. Cell strains are cells that have been adapted to culture but, unlike cell lines, have a finite division potential.
An immortalised cell line is a population of cells from a multicellular organism that would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division. The cells can therefore be grown for prolonged periods in vitro. The mutations required for immortality can occur ...
HeLa (/ ˈ h iː l ɑː /) is an immortalized cell line used in scientific research. It is the oldest human cell line and one of the most commonly used. [1] [2] HeLa cells are durable and prolific, allowing for extensive applications in scientific study.
For example, a "flu strain" is a certain biological form of the influenza or "flu" virus. These flu strains are characterized by their differing isoforms of surface proteins. New viral strains can be created due to mutation or swapping of genetic components when two or more viruses infect the same cell in nature. [3]
There are two principal ways in which a cell line can become contaminated: cell cultures are often exchanged between research groups; if, during handling, a sample is contaminated and then passed on, subsequent exchanges of cells will lead to the contaminating population being established, although parts of the supposed cell line are still genuine.
MRC-5 cell. MRC-5 (Medical Research Council cell strain 5) is a diploid cell culture line composed of fibroblasts, originally developed from the lung tissue of a 14-week-old aborted Caucasian male fetus.
Since the original CHO cell line was described in 1956, many variants of the cell line have been developed for various purposes. [10] [additional citation(s) needed] In 1957, CHO-K1 was generated from a single clone of CHO cells. [16] According to an industry source, however, scientist Theodore Puck first isolated CHO-K1 in 1968. [1]
Henrietta Lacks (born Loretta Pleasant; August 1, 1920 – October 4, 1951) [2] was an African-American woman [5] whose cancer cells are the source of the HeLa cell line, the first immortalized human cell line [B] and one of the most important cell lines in medical research. An immortalized cell line reproduces indefinitely under specific ...