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Types of retinopathy caused by drug abuse include maculopathy, Saturday night retinopathy, and talc retinopathy. Common symptoms include temporary and permanent vision loss, blurred vision, and night blindness. Substances commonly associated with this condition include poppers, heroin, cocaine, methamphetamine, tobacco, and alcohol. [1]
The pharmacodynamics of cocaine involve the complex relationships of neurotransmitters (inhibiting monoamine uptake in rats with ratios of about: serotonin:dopamine = 2:3, serotonin:norepinephrine = 2:5). [110] [15] The most extensively studied effect of cocaine on the central nervous system is the blockade of the dopamine transporter protein.
Cocaine's mechanism of action in the human brain includes the inhibition of dopamine reuptake, [49] which accounts for cocaine's addictive properties, as dopamine is the critical neurotransmitter for reward. However, cocaine is more active in the dopaminergic neurons of the ventral tegmental area than the substantia nigra.
Classic photoreceptors (rods and cones) also feed into the novel visual system, which may contribute to color constancy. ipRGCs could be instrumental in understanding many diseases including major causes of blindness worldwide like glaucoma, a disease that affects ganglion cells, and the study of the receptor offered potential as a new avenue ...
How does pink cocaine affect someone? It can be hard to determine how the drug cocktail may affect someone after ingesting it. WebMD said this is due to several factors: the types of drugs mixed ...
Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the central and peripheral nervous system, muscle, and many other tissues of many organisms.
Hallucinogen persisting perception disorder (HPPD) is a non-psychotic disorder in which a person experiences apparent lasting or persistent visual hallucinations or perceptual distortions after using drugs, [1] including but not limited to psychedelics, dissociatives, entactogens, tetrahydrocannabinol (THC), and SSRIs.
Amphetamines have an effect on norepinephrine levels similar to that of cocaine in that they both increase NE levels in the brain. [29] Amphetamine-like drugs are substrates for monoamine transporters , include NET, that cause a reversal in the direction of neurotransmitter transport.