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The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 and alpha-1 (HBA1; this gene) coding sequences are identical.
The human alpha globin gene cluster is located on chromosome 16 and spans about 30 kb, including seven alpha like globin genes and pseudogenes: 5'- HBZ - HBZP1 - HBM - HBAP1 - HBA2 - HBA1 - HBQ1-3'. The HBA2 (α 2) and HBA1 (α 1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but ...
Two globin chains that have heme groups combine to form hemoglobin. One of the chains is an alpha chain and the other is a non-alpha chain. Non-alpha chain nature in hemoglobin molecules varies due to different variables. Fetuses have a non-alpha chain called gamma and after birth it is then called beta. The beta chain will pair with the alpha ...
The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a ...
The distance between each gene in the gene cluster can vary. The DNA found between each repeated gene in the gene cluster is non-conserved. [10] Portions of the DNA sequence of a gene is found to be identical in genes contained in a gene cluster. [5] Gene conversion is the only method in which gene clusters may become homogenized. Although the ...
The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 ...
This 'globin fold' typically consists of eight alpha helices, although some proteins have additional helix extensions at their termini. [4] Since the globin fold contains only helices, it is classified as an all-alpha protein fold. The globin fold is found in its namesake globin families as well as in phycocyanins. The globin fold was thus the ...
Mu hemoglobin is a predicted protein encoded in the HBM gene. The mRNA is expressed at moderate levels, but the protein has not been detected by mass spectrometry. [1] [2] [3] The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta1 - 3'.