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Initial experiments revolved around the concept that any electrical change that is brought about in neurons must occur through the action of ions. The German physical chemist Walther Nernst applied this concept in experiments to discover nervous excitability, and concluded that the local excitatory process through a semi-permeable membrane ...
From the point of view of control theory, the voltage clamp experiment can be described in terms of the application of a high-gain output feedback control law [13] to the neuronal membrane. [14] Mathematically, the membrane voltage can be modeled by a conductance-based model with an input given by the applied current I a p p ( t ...
Neuroplasticity is the process by which neurons adapt to a disturbance over time, and most often occurs in response to repeated exposure to stimuli. [27] Aerobic exercise increases the production of neurotrophic factors [note 1] (e.g., BDNF, IGF-1, VEGF) which mediate improvements in cognitive functions and various forms of memory by promoting blood vessel formation in the brain, adult ...
Richard Caton discovered electrical activity in the cerebral hemispheres of rabbits and monkeys and presented his findings in 1875. [4] Adolf Beck published in 1890 his observations of spontaneous electrical activity of the brain of rabbits and dogs that included rhythmic oscillations altered by light, detected with electrodes directly placed on the surface of the brain. [5]
The first portion of an ICSS experiment involves training subjects to respond for stimulation using a fixed-ratio 1 (FR-1) reinforcement schedule (1 response = 1 reward). In experiments involving rats, subjects are trained to press a lever for stimulation, and the rate of lever-pressing is typically the dependent variable. [1]
Within the dorsal horn of the spinal cord, activated astrocytes have the ability to respond to almost all neurotransmitters [51] and, upon activation, release a multitude of neuroactive molecules such as glutamate, ATP, nitric oxide (NO), and prostaglandins (PG), which in turn influences neuronal excitability.
The sodium channels expressed in skeletal muscle fibers have evolved into relatively pH-insensitive channels. This has been suggested to be a protective mechanism against potential over- or under-excitability in skeletal muscles, as blood pH levels are highly susceptible to change during movement.
NMT is a diverse disorder. As a result of muscular hyperactivity, patients may present with muscle cramps, stiffness, myotonia-like symptoms (slow relaxation), associated walking difficulties, hyperhidrosis (excessive sweating), myokymia (quivering of a muscle), fasciculations (muscle twitching), fatigue, exercise intolerance, myoclonic jerks and other related symptoms.