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Mercaptopurine (6-MP), sold under the brand name Purinethol among others, is a medication used for cancer and autoimmune diseases. [2] Specifically it is used to treat acute lymphocytic leukemia (ALL), acute promyelocytic leukemia (APL), Crohn's disease , and ulcerative colitis .
Mercaptopurine, also known as 6-Mercaptopurine, 6-MP and Purinethiol. Azathioprine, also known as Imuran (US) or Azasan, which metabolises to 6-MP. Methotrexate, which inhibits folic acid. Mercaptopurine is a cytostatic drug that is an antimetabolite. The mercaptopurine molecule mimics purine, which is necessary for the synthesis of DNA. With ...
It is nonenzymatically cleaved to mercaptopurine, a purine analogue that inhibits DNA synthesis. By preventing the clonal expansion of lymphocytes in the induction phase of the immune response, it affects both cell immunity and humoral immunity. It also successfully suppresses autoimmunity. Mercaptopurine; Thioguanine; Nucleoside analogues ...
Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents and immunosuppressive drugs. Genetic polymorphisms that affect this enzyme's activity are correlated with variations in sensitivity and toxicity to such drugs. About 1/300 individual is deficient for the enzyme. [5]
It might cause unknown side effects or infections if bacteria grow in the solution. Ew. Read on for everything you need to know about semaglutide expiration, including the health risks and what to ...
An epidemiologist has slammed the Trump White House’s deletion of public health data from federal websites as “deeply disturbing.” The “widespread tampering and dismantling of really ...
Thioguanine Mercaptopurine Azathioprine. The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis), and organ transplant recipients. Metabolism is catalyzed by S-methyltransferase and nudix hydrolase 15 (NUDT15). [1]
No eggs, no problem. These easy dinner and dessert recipes don't require any expensive eggs, including meatballs, cookies, casseroles, chicken parm, and more.