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Methylephedrine, sold under the brand name Metheph among others, is a sympathomimetic medication described as an antiasthmatic agent and used to treat coughing and nasal congestion. [ 3 ] [ 4 ] [ 1 ] It is reported to be used in various over-the-counter cough and cold preparations throughout the world, including Japan .
Levmetamfetamine is used to treat nasal congestion related to the common cold and allergic rhinitis. It is available in the form of an inhaler containing 50 mg total per inhaler and delivering between 0.04 and 0.15 mg of the drug per inhalation. [2]
Vaccine combinations (few exceptions), antibiotics, low-dose steroids (less than 20 mg per day), minor infections with low fever (below 38.5º Celsius), diarrhea, malnutrition, kidney or liver disease, heart or lung disease, non-progressive encephalopathy, well controlled epilepsy or advanced age, are not contraindications to vaccination.
Their effectiveness by themselves in the common cold appears to have a small benefit in adults. [1] Topical decongestants should only be used by patients for a maximum of 5–7 days in a row, because rebound congestion may occur in the form of rhinitis medicamentosa. When used in adults for a short period of time side effects appear to be few. [1]
The range contains 200 mg of guaifenesin which helps to relieve chesty cough, in addition to 1000 mg of paracetamol and 12.2 mg of phenylephrine hydrochloride (12.18 mg of phenylephrine hydrochloride in Lemsip Max All In One Liquid) which aims to relieve headache, sore throat, fever, body aches and pains, and a blocked nose.
Approximately 90% of a dose of phenylpropanolamine is excreted in the urine unchanged within 24 hours. [4] [6] [7] [5] About 4% of excreted material is in the form of metabolites. [4] The elimination half-life of immediate-release phenylpropanolamine is about 4 hours, with a range in different studies of 3.7 to 4.9 hours.
Levomethamphetamine, also known as levmetamfetamine or l-desoxyephedrine, and sold under the brand name Vicks VapoInhaler among others, is an optical isomer of methamphetamine primarily used as a topical nasal decongestant. [2]
Propylhexedrine works mainly as an adrenergic agonist, when used at therapeutic doses in an inhaler dosage form. [21] This restricts the blood vessels in the nose and reduces swelling; thereby, it relieves nasal congestion. [22] At higher doses, propylhexedrine affects the central nervous system as a norepinephrine–dopamine releasing agent ...