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Flunarizine is a selective calcium antagonist with moderate other actions including antihistamine, serotonin receptor blocking and dopamine D 2 blocking activity. Compared to other calcium channel blockers such as dihydropyridine derivatives, verapamil and diltiazem, flunarizine has low affinity to voltage-dependent calcium channels.
Both newer and older drugs are generally equally effective in new onset epilepsy. [42] The newer drugs tend to have fewer side effects. [42] For newly diagnosed partial or mixed seizures, there is evidence for using gabapentin, lamotrigine, oxcarbazepine or topiramate as monotherapy. [42]
Most of these patients were using the only effective drug then available, bromide, which had terrible side effects and limited efficacy. On phenobarbital, their epilepsy was much improved: The worst [clarification needed] patients had fewer and lighter seizures and some patients became seizure-free. In addition, they improved physically and ...
[2]: 118 As of 2015, two cases of AHS have been reported that manifested during long-term treatment with multiple anti-seizure medications. Death due to multiple organ failure can occur; symptoms also mimic lymphoma and AHS has been called "pseudolymphoma" as a result. Changing the medications involved to those in a different class can avoid ...
Seizure [Note 10] Agitation (restlessness) Stably and for life, alters natural processes in the biological systems of the mitochondria of the nervous system. [6] [7] Inhibits the efficiency of the electron transport chain. [8] [9] Pain at the injection site; Injection site abscess
It has been used in convulsive therapy, and was found to be effective—primarily for depression—but side effects such as uncontrolled seizures were difficult to avoid. [1] In 1939, pentylenetetrazol was replaced by electroconvulsive therapy , which is easier to administer, as the preferred method for inducing seizures in England's mental ...
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