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Chemotherapy-induced acral erythema, also known as palmar-plantar erythrodysesthesia or hand-foot syndrome is reddening, swelling, numbness and desquamation (skin sloughing or peeling) on palms of the hands and soles of the feet (and, occasionally, on the knees, elbows, and elsewhere) that can occur after chemotherapy in patients with cancer.
Epothilones cause microtubule disruption (like taxane-based drugs), which impairs axonal transport and leads to hyperexcitability of peripheral neurons. They can cause neuropathy characterized by paresthesias, numbness, and pain in the hands and feet.
Whilst hearing loss is a common symptom in many diseases of the ear, for example in otosclerosis (abnormal bone growth in the ear), [3] the white, chalky patches on the tympanic membrane are fairly characteristic of tympanosclerosis. Cholesteatoma is similar in appearance but the whiteness is behind the tympanic membrane, rather than inside.
For example, very curvy ear canals, narrow ear canals, or surgical ears are more prone to earwax buildup. When wax builds up, it causes muffled hearing, tinnitus, or aural fullness (plugged-up ...
Friction or repeated pressure typically cause them, so while you can get calluses anywhere, they’re most common in places where your skin is constantly rubbing against something — like your feet.
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Keratosis obturans is a relatively uncommon ear disease, where a dense plug of keratin, formed by abnormal accumulation of desquamated skin in sheet-like layers , forms in the bony (deeper) part of the external auditory canal. [1]
Cotton swabs "really weren't made to clean your ears — all they do is just push the wax deeper down into your ear canal and this causes an impaction," Dr. Tonia L. Farmer advised.