Search results
Results From The WOW.Com Content Network
The human thromboxane A (TXA) synthase is a 60 kDa cytochrome P450 protein with 533 amino acids and a heme prosthetic group.This enzyme, anchored to the endoplasmic reticulum, is found in platelets, monocytes, and several other cell types.
Thromboxane A 2 (TXA 2) is generated from prostaglandin H 2 by thromboxane-A synthase in a metabolic reaction which generates approximately equal amounts of 12-hydroxyheptadecatrienoic acid (12-HHT). Aspirin irreversibly inhibits platelet cyclooxygenase 1 preventing the formation of prostaglandin H 2, and therefore TXA 2.
Thromboxane-A synthase, an enzyme found in platelets, converts the arachidonic acid derivative prostaglandin H 2 to thromboxane. People with asthma tend to have increased thromboxane production, and analogs of thromboxane act as bronchoconstrictors in patients with asthma.
A decrease in Thromboxane-A synthase leads to an increase in prostaglandin E2 levels which may affect erythroid precursor cells by suppressing them which likely leads to refractory anemia. [ 15 ] There are still unanswered questions about the effect of a compromised TBXAS1 gene function and its effect in Ghosal hematodiaphyseal dysplasia.
Prostaglandin H 2 (PGH 2), or prostaglandin H2 (PGH2), is a type of prostaglandin and a precursor for many other biologically significant molecules. It is synthesized from arachidonic acid in a reaction catalyzed by a cyclooxygenase enzyme. [ 2 ]
All other prostanoids originate from PGH (as PGH 1, PGH 2, or PGH 3). The image at right shows how PGH 2 (derived from Arachidonic acid) is converted: By PGE synthetase into PGE2 (which in turn is converted into PGF2) By PGD synthetase into PGD2; By Prostacyclin synthase into prostacyclin (PGI2) By Thromboxane synthase into thromboxanes TXA
The thromboxane receptor (TP) also known as the prostanoid TP receptor is a protein that in humans is encoded by the TBXA2R gene, The thromboxane receptor is one among the five classes of prostanoid receptors [5] and was the first eicosanoid receptor cloned. [6] The TP receptor derives its name from its preferred endogenous ligand thromboxane A ...
Furegrelate is able to bind to the enzyme thromboxane A2 synthase. By binding to thromboxane A2 synthase it negates the effects and prevents it from acting like a vasoconstrictor. Because of this Furegrelate is capable of preventing several diseases involving thrombosis, the occurrence of blood clots that block veins or arteries. Furegrelate is ...