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Patients with acute porphyrias should avoid using Miconazole and Ketoconazole. [8] Miconazole Miconazole is a widely used topical antifungal medication for the treatment of many fungal infections, namely skin infections, nail infections and vaginal candidiasis. The drug is usually formulated in creams, powders and sprays.
For breastfeeding mothers topical miconazole is the most effective treatment for treating candidiasis on the breasts. [68] Gentian violet can be used for thrush in breastfeeding babies. [14] Systemic treatment with antifungals by mouth is reserved for severe cases or if treatment with topical therapy is unsuccessful.
Antifungal resistance to drugs in the azole class tends to occur gradually over the course of prolonged drug therapy, resulting in clinical failure in immunocompromised patients (e.g., patients with advanced HIV receiving treatment for thrush or esophageal Candida infection). [15]
Before oral antifungal therapies are used to treat nail disease, a confirmation of the fungal infection should be made. [36] Approximately half of suspected cases of fungal infection in nails have a non-fungal cause. [36] The side effects of oral treatment are significant and people without an infection should not take these drugs. [36]
Ketoconazole, sold under the brand name Nizoral, among others, is an antiandrogen, antifungal, and antiglucocorticoid medication used to treat a number of fungal infections. [11] Applied to the skin it is used for fungal skin infections such as tinea, cutaneous candidiasis, pityriasis versicolor, dandruff, and seborrheic dermatitis. [12]
Nystatin, sold under the brand name Mycostatin among others, is an antifungal medication. [1] It is used to treat Candida infections of the skin including diaper rash, thrush, esophageal candidiasis, and vaginal yeast infections. [1] It may also be used to prevent candidiasis in those who are at high risk. [1]
Amphotericin B deoxycholate is the most common treatment antifungal agent used to treat Candida infections. [4] Topical antifungal agents are commonly taken in 3 forms: oral suspension, ointment and powder. [4] Oral suspension is mainly used to treat thrush whereas ointment is directly applied onto the infected section. [4]
The results showed 0.8% terconazole mycologic cure rates were 83.3% within 1–3 days of starting treatment, 83.3% within 8–11 days of treatment and 58.3% within 30–35 days of treatment. [5] The suppository is more effective after a long-term follow-up than terconazole as a cream or other intravaginal treatments.