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Disulfiram is a medication used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (drinking alcohol). Disulfiram works by inhibiting the enzyme aldehyde dehydrogenase (specifically the ALDH2 enzyme [3]), causing many of the effects of a hangover to be felt immediately following alcohol consumption.
[1] [2] The reaction has been variously termed a disulfiram-like reaction, alcohol intolerance, and acetaldehyde syndrome. [ 3 ] The prototypical drug of this group is disulfiram (brand name Antabuse), which acts as an acetaldehyde dehydrogenase inhibitor , preventing the metabolism of acetaldehyde into acetic acid , and is used in the ...
Disulfiram-alcohol reaction (DAR) is the effect of the interaction in the human body of alcohol drunk with disulfiram or some types of mushrooms. [ 1 ] [ 2 ] The DAR is key to disulfiram therapy that is widely used for alcohol-aversive treatment and management of other addictions (e.g. cocaine [ 3 ] [ 4 ] use).
ATC code N07 Other nervous system drugs is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
The reaction is the result of an accumulation of acetaldehyde, a metabolic byproduct of the catabolic metabolism of alcohol, and is caused by an aldehyde dehydrogenase 2 deficiency. [ 4 ] This syndrome has been associated with lower than average rates of alcoholism, possibly due to its association with adverse effects after drinking alcohol. [ 5 ]
Yields: 6 servings. Prep Time: 40 mins. Total Time: 1 hour 45 mins. Ingredients. 2 tbsp. olive oil, plus more for the baking dish. 1. medium yellow onion, chopped
GOP Rep. Byron Donalds, a top Trump ally in Congress, seems more vocal about running for Florida governor in 2026 in the race to succeed term-limited Republican Gov. Ron DeSantis.
10. Hopdoddy. Hopdoddy Burger Bar serves elevated burgers made from fresh, never-frozen beef. Its patties are ground in-house and hand-formed every day for the best quality.