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High-dose estrogen therapy is effective in the treatment of about 35% of cases of breast cancer in women who are ... [114] [110] Low doses (e.g., 50 μg/day) and ...
Estrogen dosages for menopausal hormone therapy; Route/form Estrogen Low Standard High Oral: Estradiol: 0.5–1 mg/day: 1–2 mg/day: 2–4 mg/day Estradiol valerate:
Estradiol is an estrogen, or an agonist of the nuclear estrogen receptors (ERs), the estrogen receptor alpha (ERα) and the estrogen receptor beta (ERβ). [1] [2] [6] In one study, the EC 50 Tooltip half-maximal effective concentration value of estradiol for the human ERα was 50 pM (0.05 nM) and for the human ERβ was 200 pM (0.2 nM).
But using a low-dose vaginal estrogen cream twice a week or the hormone dehydroepiandrosterone (DHEA), a suppository that’s typically applied nightly, helps restore acidity and repairs the tissue.
Research has suggested that estrogen plus progestogen therapy may increase the risk of heart attacks, stroke, breast cancer, blot clots, and dementia in postmenopausal women. Taking the lowest effective dose of both estrogen and a progestogen may reduce risks. [1]
Estradiol only recommended for use for the shortest period of time and at the lowest effective dose due to its adverse-effects profile. [29] There is the potential for a range of adverse effects in breasts, skin, eyes, cardiovascular, gastrointestinal, genitourinary or central nervous systems. [29]
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