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The typical dosage is either 1.5 mg taken once or 0.75 mg taken 12–24 hours apart. [37] The effectiveness in both methods is similar. [ 37 ] The most widely used form of oral emergency contraception is the progestin-only pill , which contains a 1.5 mg dosage of levonorgestrel. [ 36 ]
However, a study in the Mirena application for FDA approval found a lower continuation of breastfeeding at 75 days in hormonal IUD users (44%) versus copper IUD users (79%). [39]: 37 When using Mirena, about 0.1% of the maternal dose of levonorgestrel can be transferred via milk to the nursed infant. [40]
Mirena [30] Skyla [31] Liletta [32] Kyleena [33] Hormone (total in device) None 52 mg levonorgestrel 13.5 mg levonorgestrel 52 mg levonorgestrel 19.5 mg levonorgestrel Initial amount released None 20 μg/day 14 μg/day 18.6 μg/day 16 μg/day Approved effectiveness 10 years (12 years) 5 years (10 years) 3 years 3 years (5 years) 5 years
Each box, as supplied by the manufacturer, contains three blister packs of 28 tablets packaged in individual boxes. Each blister pack of 28 tablets contains 24 pink active pills containing drospirenone 3 mg, ethinylestradiol 20 mcg, and levomefolate calcium 0.451 mg and four light orange inactive pills containing of levomefolate calcium 0.451 mg. [7] [9]
The rate of amenorrhea after one year of use is in the range of 20 to 50%, although most users of the hormonal IUDs Mirena and Liletta experience a marked decrease in menstrual bleeding, which is beneficial and has led to reported high rates of user satisfaction. Levonorgestrel IUDs have also been used been shown to induce amenorrhea.
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