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The serrated polyposis syndrome (SPS) is a relatively rare condition characterized by multiple and/or large serrated polyps of the colon. Serrated polyps include SSLs, hyperplastic polyps, and traditional serrated adenomas. Diagnosis of this disease is made by the fulfillment of any of the World Health Organization's (WHO) clinical criteria. [4]
Micrograph of a sessile serrated adenoma. H&E stain. Sessile serrated adenomas are characterized by (1) basal dilation of the crypts, (2) basal crypt serration, (3) crypts that run horizontal to the basement membrane (horizontal crypts), and (4) crypt branching. The most common of these features is basal dilation of the crypts.
Neoplastic polyps of the bowel are often benign hence called adenomas. An adenoma is a tumor of glandular tissue, that has not (yet) gained the properties of cancer. [citation needed] The common adenomas of the colon (colorectal adenoma) are the tubular, tubulovillous, villous, and sessile serrated (SSA). [18]
Traditional serrated adenoma seen under microscopy with H&E stain, showing serrated crypts. SPS may occur with one of two phenotypes: distal or proximal. [6] The distal phenotype may demonstrate numerous small polyps in the distal colon and rectum, whereas the proximal phenotype may be characterized by relatively fewer, but larger polyps in the proximal colon (cecum, ascending colon, etc.). [6]
The dog then causes further trauma to the skin by itching and rubbing at the area, leading to a secondary bacterial infection." Acute moist dermatitis: Symptoms A patch of moist, inflamed skin ...
A sessile serrated adenoma or traditional serrated adenoma is suspected if there is either of the following: [4] Nuclear stratification; Loss of polarity; Dysplasia; A sessile serrated adenoma is suspected in case of any of the following: [4] Size ≥0.5 cm; Location in right colon; If both are present, it is almost always an SSA.
Sessile serrated adenoma: Colorectal Similar to hyperplastic with hyperserration, dilated/branched crypt base, prominent mucin cells at crypt base Yes Serrated polyposis syndrome: Inflammatory Non-specific Raised mucosa/submucosa with inflammation If dysplasia develops Inflammatory bowel disease, ulcers, infections, mucosal prolapse
Traditional serrated adenoma is a premalignant type of polyp found in the colon, often in the distal colon (sigmoid, rectum). Traditional serrated adenomas are a type of serrated polyp, and may occur sporadically or as a part of serrated polyposis syndrome. Traditional serrated adenomas are relatively rare, accounting for less than 1% of all ...