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Panlobular emphysema, also called panacinar emphysema, affects all of the alveoli in a lobule, and can involve the whole lung or mainly the lower lobes. [ 18 ] [ 24 ] This type of emphysema is associated with alpha-1 antitrypsin deficiency (A1AD or AATD), and Ritalin lung , [ 24 ] and is not related to smoking.
However, in some medical circles, it can instead be more commonly known as Macklin's Syndrome after L. Macklin, in 1939, and C.C. and M.T. Macklin, in 1944, who cumulatively went on to describe the pathophysiology in more detail. [3] Subcutaneous emphysema can result from puncture of parts of the respiratory or gastrointestinal systems.
In a highly compliant lung, as in emphysema, the elastic tissue is damaged by enzymes. These enzymes are secreted by leukocytes (white blood cells) in response to a variety of inhaled irritants, such as cigarette smoke. Patients with emphysema have a very high lung compliance due to the poor elastic recoil. They have extreme difficulty exhaling ...
Emphysema is a chronic lung condition that causes shortness of breath. The disease is generally caused by cigarette smoking (the 78-year-old Lynch is a lifelong smoker) or exposure to pollutants.
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The main symptom is usually severe central chest pain. Other symptoms include laboured breathing, voice distortion (as with helium) and subcutaneous emphysema, specifically affecting the face, neck, and chest. [4] Pneumomediastinum can also be characterized by the shortness of breath that is typical of a respiratory system problem.