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Clonazepam, sold under the brand name Klonopin among others, is a benzodiazepine medication used to prevent and treat anxiety disorders, seizures, bipolar mania, agitation associated with psychosis, obsessive–compulsive disorder (OCD), and akathisia. [11]
The long-term effects of benzodiazepines are very similar to the long-term effects of alcohol consumption (apart from organ toxicity) and other sedative-hypnotics. Withdrawal effects and dependence are not identical. Dependence can be managed, with a medical professional of course, but withdrawal can be fatal.
With most benzodiazepines, noticeable effects usually wear off within a few hours. Nevertheless, as long as the drug is present it will exert subtle effects within the body. These effects may become apparent during continued use or may appear as withdrawal symptoms when dosage is reduced or the drug is stopped. [citation needed]
The use of benzodiazepines has a profound effect on almost every aspect of brain and body function, either directly or indirectly. [ 39 ] With chronic benzodiazepine use, tolerance develops rapidly to most of its effects, so that, when benzodiazepines are withdrawn, various neurotransmitter systems go into overdrive due to the lack of ...
Chlordiazepoxide acts on benzodiazepine allosteric sites that are part of the GABA A receptor/ion-channel complex and this results in an increased binding of the inhibitory neurotransmitter GABA to the GABA A receptor thereby producing inhibitory effects on the central nervous system and body similar to the effects of other benzodiazepines. [25]
1. Pancreatitis. Pancreatitis (inflammation of the pancreas) was reported in clinical trials on Ozempic. But the results weren’t conclusive. If pancreatitis is indeed a risk, it seems to be ...
This effect of benzodiazepines requires the presence of the neurotransmitter GABA and results in enhanced inhibitory effects of the neurotransmitter GABA acting on GABA A receptors. [7] Clorazepate, like other benzodiazepines, is widely distributed and is highly bound to plasma proteins; clorazepate also crosses readily over the placenta and ...
A Maryland jury finds 'Real Housewives of Potomac' star Karen Huger guilty of driving under the influence and several other charges after she was arrested earlier this year.