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A 1991 review reported that the influences of spironolactone on androgen levels in women were variable and inconsistent. [78] Spironolactone has shown no significant effect on levels of testosterone, estradiol, luteinizing hormone, and follicle-stimulating hormone in men. [146] [78]
Spironolactone has been found in some studies to increase levels of estradiol, an estrogen, although many other studies have found no changes in estradiol levels. [ 109 ] [ 134 ] The mechanism of how spironolactone increases estradiol levels is unclear, but it may involve inhibition of the inactivation of estradiol into estrone and enhancement ...
A dosage of two to six 100 μg/day transdermal estradiol patches can achieve mean levels of estradiol in the area of 200 to 400 pg/mL and can be used as a form of high-dose estrogen therapy, for instance to suppress testosterone levels in the treatment of prostate cancer in men and in feminizing hormone therapy for transgender women.
A prescription medication, spironolactone blocks androgen production that decreases the amount of DHT, the hormone that causes hair follicles to shrink and hair shafts to become thinner and finer.
3. Spironolactone. Another androgen- and DHT-targeting treatment that can work for women is spironolactone. It’s sometimes prescribed off-label to treat hair loss that occurs due to polycystic ...
Women's hair loss can be caused by many factors, from alopecia to pregnancy to poor diet. ... “Your levels of androgens, ... Spironolactone is yet another common oral medication used for its ...