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Charles Alfred "Chuck" [1] Vacanti (born 1950) is a researcher in tissue engineering [2] and stem cells and the Vandam/Covino Professor of Anesthesiology, Emeritus, at Harvard Medical School. [3] He is a former head of the Department of Anesthesiology at the University of Massachusetts and Brigham and Women’s Hospital , now retired.
A major technology of regenerative medicine is tissue engineering, [2] which has variously been defined as "an interdisciplinary field that applies the principles of engineering and the life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function", or "the creation of new tissue by the ...
He is a widely recognized and cited researcher in biotechnology, especially in the fields of drug delivery systems and tissue engineering. [ 4 ] [ 6 ] [ 7 ] He is the most cited engineer in history [ 8 ] and one of the 10 most cited individuals in any field, [ 9 ] having authored over 1,500 scientific papers.
On the other hand, the strict meaning of "tissue culture" refers to the culturing of tissue pieces, i.e. explant culture. Tissue culture is an important tool for the study of the biology of cells from multicellular organisms. It provides an in vitro model of the tissue in a well defined environment which can be easily manipulated and analysed ...
Skin grafting, invented in the late 19th century, can be thought of as the earliest major attempt to recreate bodily tissue to restore structure and function. [11] Advances in transplanting body parts in the 20th century further pushed the theory that body parts could regenerate and grow new cells.
Micro-mass cultures of C3H-10T1/2 cells at varied oxygen tensions stained with Alcian blue. A commonly applied definition of tissue engineering, as stated by Langer [3] and Vacanti, [4] is "an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve [Biological tissue] function or a ...
Biological engineering is a science-based discipline founded upon the biological sciences in the same way that chemical engineering, electrical engineering, and mechanical engineering [7] can be based upon chemistry, electricity and magnetism, and classical mechanics, respectively.
Different models of 3D printing tissue and organs. Three dimensional (3D) bioprinting is the use of 3D printing–like techniques to combine cells, growth factors, bio-inks, and biomaterials to fabricate functional structures that were traditionally used for tissue engineering applications but in recent times have seen increased interest in other applications such as biosensing, and ...