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The deposition of amyloid proteins in the bone marrow without causing plasma cell dyscrasias is called amyloidoma. It is commonly found in cervical, lumbar, and sacral vertebrae. Those affected may be presented with bone pain due to bone lysis, lumbar paraparesis, and a variety of neurological symptoms. Vertebral fractures are also common.
One such stain is Congo Red, which binds specifically to the amyloid deposit and can be characterized by various lighting methods. [7] Under polarized light, the amyloid deposits while show pathognomonic apple green birefringence, and under plain light the deposits will appear a light salmon pink color. [ 7 ]
The crystals do not birefringe and are negative when stained with Congo red stain, but may be positive by phosphotungstic acid hematoxylin and periodic acid-Schiff (PAS) staining. [3] [4] The most common immunoglobulin deposited in the crystals is IgG. [1] When the antibodies in the crystals are tested, they are almost always kappa light chain ...
Due to a color change from blue to red at pH 3.0–5.2, Congo red can be used as a pH indicator. Since this color change is an approximate inverse of that of litmus, it can be used with litmus paper in a simple parlor trick: add a drop or two of Congo red to both an acid solution and a base solution. Dipping red litmus paper in the red solution ...
Wright's stain is a hematologic stain that facilitates the differentiation of blood cell types. It is classically a mixture of eosin (red) and methylene blue dyes. It is used primarily to stain peripheral blood smears, urine samples, and bone marrow aspirates, which are examined under a light microscope.
CAA is associated with brain hemorrhages, particularly microhemorrhages.The accumulation of amyloid beta peptide deposits in the blood vessel walls results in damage of the blood vessels and hindrance of normal blood flow, making blood vessels more prone to bleeding [10] Since CAA can be caused by the same amyloid protein that is associated with Alzheimer's dementia, brain bleeds [11] are more ...
The red bone marrow is a key element of the lymphatic system, being one of the primary lymphoid organs that generate lymphocytes from immature hematopoietic progenitor cells. [24] The bone marrow and thymus constitute the primary lymphoid tissues
The addition of Giemsa to Wright's stain increases the brightness of the "reddish-purple" color of the cytoplasmic granules. [1] [21] The Wright's and Wright-Giemsa stains are two of the Romanowsky-type stains in common use in the United States and are mainly used for the staining of blood and bone marrow films. [21] [1]