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Methemoglobinemia, or methaemoglobinaemia, is a condition of elevated methemoglobin in the blood. [2] Symptoms may include headache, dizziness, shortness of breath, nausea, poor muscle coordination, and blue-colored skin (cyanosis). [ 2 ]
It is recommended that treatment with methylene blue requires two doses before being deemed ineffective. If symptoms of methemoglobinemia are still present after the second dosage, alternative treatments, including ascorbic acid, exchange transfusion, and hyperbaric oxygen therapy, can be considered. However, no additional antidote has been ...
Hemoglobin M disease is often not life-threatening and treatment is not necessary. There is no existing effective treatment, including methylene blue (MB) and ascorbic acid used in treating acquired methemoglobinemia. [12] MB is an oxidant and it is not used to treat hemoglobin M disease. They are prone to develop symptomatic methemoglobinemia ...
Main symptoms that may appear in anemia [20] The hand of a person with severe anemia (on the left, with ring) compared to one without (on the right). A person with anemia may not have any symptoms, depending on the underlying cause, and no symptoms may be noticed, as the anemia is initially mild, and then the symptoms become worse as the anemia worsens.
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Common side effects include headache, nausea, and vomiting. While use during pregnancy may harm the fetus, not using it in methemoglobinemia is likely more dangerous. [6] [2] Methylene blue was first prepared in 1876, by Heinrich Caro. [9] It is on the World Health Organization's List of Essential Medicines. [10]
Symptoms include a blueish or greenish coloration of the blood (cyanosis), skin, and mucous membranes, even though a blood count test may not show any abnormalities in the blood. This discoloration is caused by greater than 5 grams per cent of deoxyhemoglobin, or 1.5 grams per cent of methemoglobin, or 0.5 grams per cent of sulfhemoglobin, all ...
Hemoglobin oxygenation dissociation curve. In the case of methemoglobinemia the curve is shifted to the left given the higher affinity for oxygen. [22] Methemoglobinemia can be acquired or congenital. It occurs when the iron in hemoglobin is oxidized from Fe 2+ to Fe 3+, leading to poor binding of oxygen. Additionally, the oxygen that is ...