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Glucose transporter 1 (or GLUT1), also known as solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), is a uniporter protein that in humans is encoded by the SLC2A1 gene. [1] GLUT1 facilitates the transport of glucose across the plasma membranes of mammalian cells. [ 2 ]
A person with GLUT1 deficiency syndrome has a 50% chance of passing along the altered SLC2A1 gene to his or her offspring. [ 16 ] In a study focusing on GLUT1 mice model brain slides, physiological glucose concentration was found to be a modulator of frequency oscillations and less frequent 30–50 Hz or gamma oscillations.
Name Distribution Notes GLUT1: Is widely distributed in fetal tissues. In the adult, it is expressed at highest levels in erythrocytes and also in the endothelial cells of barrier tissues such as the blood–brain barrier. It is responsible for the low level of basal glucose uptake required to sustain respiration in all cells.
GLUT1 is a hydrophobic protein and 50% of GLUT1 is in the lipid bilayer. GLUT1 is present in the placenta, brain, epithelial cells of the mammary gland, transformed cells, and fetal tissue. [5] Due to its ubiquitous presence, it is proposed that GLUT1 is at least somewhat responsible for basal glucose uptake. [5]
A suspected contributor to familial PED is a mutation in the GLUT1 gene, SLC2A1, which codes for the transporter GLUT1, a protein responsible for glucose entry across the blood–brain barrier. [5] It is not thought that the mutation causes a complete loss of function of the protein but rather only slightly reduces the transporter's activity. [8]
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72961 Ensembl ENSG00000104888 ENSMUSG00000070570 UniProt Q9P2U7 Q3TXX4 RefSeq (mRNA) NM_020309 NM_182993 RefSeq (protein) NP_064705 NP_892038 Location (UCSC) Chr 19: 49.43 – 49.44 Mb Chr 7: 44.81 – 44.83 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene. The protein encoded by this ...
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