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Low-dose spironolactone is ... a 10-year observational study found that the incidence of depression in 196 transgender women taking high-dose spironolactone in ...
[96] [104] [105] Spironolactone has been found to decrease the bioavailability of high doses of oral estradiol. [28] Although widely employed, the use of spironolactone as an antiandrogen in transgender women has recently been questioned due to the various shortcomings of the medication for such purposes. [28]
A study found that oral spironolactone had "about 10 to 20% of the feminizing effect of cyproterone acetate" on sexual differentiation in male rat fetuses, with a dose of 40 mg/day spironolactone having an effect equal to 1–3 mg/day cyproterone acetate.
Nearly 20 years later, doctors like Harry Benjamin (the "American father of transgender health care," Boulware notes) began using hormones to treat people experiencing gender dysphoria.And ...
Template:Medications and dosages used in hormone therapy for transgender men References ^ Hembree WC, Cohen-Kettenis PT, Gooren L, Hannema SE, Meyer WJ, Murad MH, Rosenthal SM, Safer JD, Tangpricha V, T'Sjoen GG (November 2017).
Cyproterone acetate (CPA), sold alone under the brand name Androcur or with ethinylestradiol under the brand names Diane or Diane-35 among others, is an antiandrogen and progestin medication used in the treatment of androgen-dependent conditions such as acne, excessive body hair growth, early puberty, and prostate cancer, as a component of feminizing hormone therapy for transgender individuals ...
Antiandrogens: Bicalutamide has been used as an alternative puberty blocker in transgender girls for whom GnRH agonists were denied by insurance. [56] [57] The antiandrogens spironolactone and cyproterone acetate are not as strong. [57] In the United States, the main providers of puberty blockers are Endo International and AbbVie. [58]
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