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Pulmonary oxygen toxicity was first described by J. Lorrain Smith in 1899 when he noted central nervous system toxicity and discovered in experiments in mice and birds that 0.43 bar (43 kPa) had no effect but 0.75 bar (75 kPa) of oxygen was a pulmonary irritant. [33] Pulmonary toxicity may be referred to as the "Lorrain Smith effect". [16]
In individuals with chronic obstructive pulmonary disease and similar lung problems, the clinical features of oxygen toxicity are due to high carbon dioxide content in the blood (hypercapnia). [1] This leads to drowsiness (narcosis), deranged acid-base balance due to respiratory acidosis, and death. [2]
Excessive exposure to oxygen can lead to oxygen toxicity, also known as oxygen toxicity syndrome, oxygen intoxication, and oxygen poisoning.There are two main ways in which oxygen toxicity can occur: exposure to significantly elevated partial pressures of oxygen for a short period of time (acute oxygen toxicity), or exposure to more modest elevations in oxygen partial pressures but for a ...
Pulmonary toxicity is the medical name for side effects on the lungs. Although most cases of pulmonary toxicity in medicine are due to side effects of medicinal drugs, many cases can be due to side effects of radiation (radiotherapy). Other (non-medical) causes of pulmonary toxicity can be chemical compounds and airborne particulate matter.
The principal conditions are decompression illness (which covers decompression sickness and arterial gas embolism), nitrogen narcosis, high pressure nervous syndrome, oxygen toxicity, and pulmonary barotrauma (burst lung). Although some of these may occur in other settings, they are of particular concern during diving activities. [1]
Fraction of inspired oxygen (F I O 2), correctly denoted with a capital I, [1] is the molar or volumetric fraction of oxygen in the inhaled gas. Medical patients experiencing difficulty breathing are provided with oxygen-enriched air, which means a higher-than-atmospheric F I O 2. Natural air includes 21% oxygen, which is equivalent to F I O 2 ...
Pulmonary toxicity occurs with exposure to partial pressures of oxygen greater than 0.5 bar (50 kPa), corresponding to 50% oxygen at normal atmospheric pressure. Signs of pulmonary toxicity begins with evidence of tracheobronchitis (inflammation of the upper airways) after an asymptomatic period between 4 and 22 hours at greater than 95% oxygen,[1]
Pulmonary alveolar proteinosis; Pulmonary arterial hypertension; Pulmonary aspiration; Pulmonary capillary hemangiomatosis; Pulmonary contusion; Pulmonary fibrosis; Pulmonary hematoma; Pulmonary hemorrhage; Pulmonary hyperplasia; Pulmonary laceration; Pulmonary oxygen toxicity; Pulmonary toxicity; Pulmonary venoocclusive disease; Pulmonary ...
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