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An enterogastrone is any hormone secreted by the mucosa of the duodenum in the lower gastrointestinal tract in response to dietary lipids that inhibits the caudal (or "forward, analward") motion of the contents of chyme. The function of enterogastrone is almost the same as gastric inhibitor peptide, it inhibits gastric secretion and motility of ...
Increases gastric emptying and small bowel motility Neuropeptide Y: Enteric nerves: Regulation of intestinal blood flow Neurotensin: Ileum: Affects gut motility; increases jejunal and ileal fluid secretion Pancreatic polypeptide: Pancreas: Inhibits pancreatic and biliary secretion Peptide YY: Colon: Inhibits food intake Somatostatin: Stomach ...
One of the actions of GLP-1 is to inhibit gastric emptying, thus slowing down its own secretion upon postprandial activation. [1] [2] Fasting plasma concentration of biologically active GLP-1 range between 0 and 15 pmol/L in humans and is increased 2- to 3-fold upon food consumption depending on meal size and nutrient composition.
Motilin is a 22-amino acid polypeptide hormone in the motilin family that, in humans, is encoded by the MLN gene. [2]Motilin is secreted by endocrine Mo cells [3] [4] (also referred to as M cells, which are not the same as the M cells, or microfold cells, found in Peyer's patches) that are numerous in crypts of the small intestine, especially in the duodenum and jejunum. [5]
Effects on endocrine secretion Effects on exocrine secretion Effects on motility Other effects Stimulus for release; Gastrin: G Cells in stomach ECL cells; parietal cells None Increases acid secretion, increases mucus growth Stimulates gastric contraction None Peptides and amino acids in lumen; gastrin releasing peptide and ACh in nervous reflexes
It can also be stimulated by a pH of 3-4 in the duodenum and by a pH of 1.5 in the stomach. Upon initiation of the reflex, the release of gastrin by G-cells in the antrum of the stomach is shut off. This in turn inhibits gastric motility and the secretion of gastric acid . [1]
Gastric inhibitory polypeptide (GIP), also known as glucose-dependent insulinotropic polypeptide, is an inhibiting hormone of the secretin family of hormones. [5] While it is a weak inhibitor of gastric acid secretion, its main role, being an incretin , is to stimulate insulin secretion.
Its role in the intestine is to greatly stimulate secretion of water and electrolytes, [12] as well as relaxation of enteric smooth muscle, dilating peripheral blood vessels, stimulating pancreatic bicarbonate secretion, and inhibiting gastrin-stimulated gastric acid secretion. These effects work together to increase motility. [13]