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Almost immediately after the infant is born, the foramen ovale and ductus arteriosus close. The major changes that are made by the body occur at the first breath (in the case of heart and lung functions) and up to weeks after birth (such as the liver's enzyme synthesis). The foramen ovale becomes the fossa ovalis as the foramen closes while ...
The patient returns to the ICU post-operatively for recovery, maintenance, and close observation; recovery time may vary, but tends to average approximately two weeks, after which the patient may be transferred to a Transitional Care Unit (TCU), and eventually to a cardiac ward.
Patent ductus arteriosus (PDA) is a medical condition in which the ductus arteriosus fails to close after birth: this allows a portion of oxygenated blood from the left heart to flow back to the lungs from the aorta, which has a higher blood pressure, to the pulmonary artery, which has a lower blood pressure.
Atrial septal defect (ASD) is a congenital heart defect in which blood flows between the atria (upper chambers) of the heart.Some flow is a normal condition both pre-birth and immediately post-birth via the foramen ovale; however, when this does not naturally close after birth it is referred to as a patent (open) foramen ovale (PFO).
PFO has long been studied because of its role in paradoxical embolism (an embolism that travels from the venous side to the arterial side). This may lead to a stroke or transient ischemic attack. Transesophageal echocardiography is considered the most accurate investigation to demonstrate a patent foramen ovale. A patent foramen ovale may also ...
Prostaglandin E2 (PGE 2), produced by both the placenta and the DA itself, is the most potent of the E prostaglandins, but prostaglandin E1 (PGE 1) also has a role in keeping the DA open. [4] PGE 1 and PGE 2 keep the ductus arteriosus open via involvement of specific PGE-sensitive receptors (such as EP4 and EP2). [5]
Fallot was the first to elegantly describe the four key features that differentiate it from other cyanotic cardiac conditions, and was prominent in the disqualification of a patent foramen ovale as a fifth feature. Fallot initially referred to it as "La maladie bleue", which is French for "the blue disease" or "cyanose cardiaque", translating ...
The most common problem with this preventive measure is the incomplete closing of the foramen secundum. [12] There is at present no drug therapy for foramen secundum atrial septal defects, although infective endocarditis is a postoperative concern. To prevent this condition, a prophylactic is used for six months after the operation. [13]