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A glioma is a type of primary tumor that starts in the glial cells of the brain or spinal cord.They are cancerous but some are extremely slow to develop. [2] [3] Gliomas comprise about 30 percent of all brain tumors and central nervous system tumours, and 80 percent of all malignant brain tumours.
In terms of low-grade gliomas, a recent study also suggests that 1p/19q co-deletion may be associated with a (1;19)(q10;p10) translocation which, like the combined 1p/19q deletion, is associated with superior overall survival and progression-free survival in low-grade glioma patients. [15]
The concept of grading of the tumors of the central nervous system, agreeing for such the regulation of the "progressiveness" of these neoplasias (from benign and localized tumors to malignant and infiltrating tumors), dates back to 1926 and was introduced by P. Bailey and H. Cushing, [1] in the elaboration of what turned out the first systematic classification of gliomas.
Two year survival rate 19.7% (adults), pediatric five year survival rate 15-25% (high grade astrocytoma) or 40% (low grade astroyctoma) Thalamic gliomas are very rare, deep-seated, generally high-grade glial neoplasms that form in the thalamus , representing 1–5% of all pediatric brain tumors. [ 1 ]
Dysembryoplastic neuroepithelial tumours are often described as a low grade tumour because about 1.2% people under the age of twenty are affected and about 0.2% over the age of twenty are affected by this tumour. [5] Since its prevalence is small among the population, it often goes misdiagnosed or even at times goes undiagnosed. [citation needed]
Management of IDH-mutant gliomas, with astrocytomas at center and right. [11] For low-grade astrocytomas, removal of the tumor generally allows functional survival for many years. In some reports, the 5-year survival has been over 90% with well-resected tumors. Indeed, broad intervention of low-grade conditions is a contested matter.
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