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Immune tolerance, also known as immunological tolerance or immunotolerance, refers to the immune system 's state of unresponsiveness to substances or tissues that would otherwise trigger an immune response. It arises from prior exposure to a specific antigen [1][2] and contrasts the immune system's conventional role in eliminating foreign antigens.
Staphylococcus aureus. Colorized scanning electron micrograph of a human neutrophil ingesting MRSA. Methicillin-resistant Staphylococcus aureus (MRSA) is a group of gram-positive bacteria that are genetically distinct from other strains of Staphylococcus aureus. MRSA is responsible for several difficult-to-treat infections in humans.
Antibiosis, also referred to as antagonism, a process of biological interaction between two or more organisms that is detrimental to at least one of them; it can also be an antagonistic association between an organism and the metabolic substances produced by another. [1] Antibiosis can occur through a variety of mechanisms, with "injury, death ...
The WHO defines antimicrobial resistance as a microorganism's resistance to an antimicrobial drug that was once able to treat an infection by that microorganism. [2] A person cannot become resistant to antibiotics. Resistance is a property of the microbe, not a person or other organism infected by a microbe. [33]
Immune system. The immune system is a network of biological systems that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to parasitic worms, as well as cancer cells and objects such as wood splinters, distinguishing them from the organism's own healthy tissue.
Antimicrobial peptides from animals, plants and fungi organised by their secondary structure content. Circle size indicates overall molecular weight of each peptide. Antimicrobial peptides are a unique and diverse group of molecules, which are divided into subgroups on the basis of their amino acid composition and structure. [3]
Tolerance to infections. Tolerance to infection, or disease tolerance, is a mechanism that host organisms can use to fight parasites or pathogens that attack the host. Tolerance is not equivalent to resistance. Disease resistance is the host trait that prevents infection or reduces the number of pathogens and parasites within or on a host.
Effector-triggered immunity. The host cell detects the presence of the pathogen directly from the molecular patterns on the pathogen and indirectly through the damage caused to the host cell by the toxins generated by the pathogen. Effector-triggered immunity (ETI) is one of the pathways, along with the pattern-triggered immunity (PTI) pathway ...